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Julio C. Barredo, M.D.

General Information

Julio C. Barredo, M.D.


  • Fax: 305-325-8387


  • Pediatrics
  • Pediatric Hematology-Oncology (Pediatrics)


English, Spanish

Clinical Areas

Acute Lymphoblastic Leukemia
Bone marrow and stem cell transplantation.
Childhood brain and spinal tumors.
Pediatric sickle cell disease.


  • American Board of Pediatrics-Pediatric Hematology-Oncology


  • Associate Chair of Pediatrics for Basic Research
  • Director, Children's Cancer Programs at UM Sylvester Comprehensive Cancer Center
  • Director, Pediatric Hematology-Oncology
  • Toppel Family Professor of Pediatric Hematology-Oncology, University of Miami Miller School of Medicine

Research Interests

Clinical Interests and Research: Pediatric Oncology. Development of new treatment strategies and clinical protocols for childhood acute lymphoblastic leukemia (ALL). Development of new therapies for relapsed childhood ALL. Member Children's Oncology Group ALL Committee. Chair COG AALL02P2: Treatment of Isolated Extramedullary Relapse of ALL.
Bone marrow and stem cell transplantation.
Childhood brain and spinal tumors.
Pediatric sickle cell disease.
Basic and Translational Research: Development of targeted therapies for childhood ALL and other childhood malignancies by investigating the biochemical, genetic and cellular mechanisms of novel molecular targets for cancer therapy. Biochemical and molecular mechanisms of action of classical and novel antifolates. Pharmacogenetics of childhood ALL.


  • Julio C. Barredo, Stephen Lauer, Amy Billet, MaryAnne Marymount, Meenakshi Devidas, Bruce Camitta, Naomi Winick, William Carroll, A. Kim Ritchey. Isolated CNS Relapse Of Acute Lymphoblastic Leukemia (All) Treated With Intensive Systemic Chemotherapy And
  • Gillespie MB, Marshall, DT, Day AT, Mitchell AO, White DR, Barredo JC. Pediatric Rhabdomyosarcoma of the Head and Neck. Current Opinions in Oncology 7: 13-22, 2006.
  • Leclerc GJ, York TA, Kinser T, Barredo JC. Molecular basis for decreased folylpoly-γ-glutamate synthetase expression in a methotrexate resistant CCRF-CEM mutant cell line. Leuekemia Research 2006, Jul 31.
  • Shayla Bergmann; Deyi Zheng; Julio Barredo; Miguel R. Abboud; Ayad A. Jaffa Renal Kallikrein: A Risk Marker for Nephropathy in Children With Sickle Cell Disease. Journal of Pediatric Hematology/Oncology. Volume 28, Issue 3, 147-153, 2006.
  • The STOP 2 Trial Investigators. Discontinuing Prophylactic Transfusions Used to Prevent Stroke in Sickle Cell Disease. NEJM, 353(26): 2769-2778, 2005.
  • JH Laver, TC Hulsey, JP Jones, M Gautreaux, JC Barredo, MR Abboud. Assessment of Barriers to Bone Marrow Donation by Unrelated African-American Potential Donors. Biology of Blood & Marrow Transplantation 7: 45-58, 2001.
  • GJ Leclerc, JC Barredo. Expression of Folylpolyglutamate Synthetase Gene mRNA Splice Variants and Protein in Primary Human Leukemia Cells, Cell Lines, and Normal Human Tissues. Clinical Cancer Research 7: 942-951, 2001.
  • JH Laver, JC Barredo, M Amylon, M Schwenn, J Kurtzberg, BM Camitta, J Pullen, M Link, M Borowitz, J Shuster. Effects of Cranial Radiation in Children with High Risk T-Cell Acute Lymphoblastic Leukemia: A Pediatric Oncology Group Report. Leukemia 14: 369-373; 2000.
  • AK Ritchey, BH Pollock, SJ Lauer, Y Andejeski, J Barredo, GR Buchanan. Improved Survival of Children with Isolated CNS Relapse of Acute Lymphoblastic Leukemia. A Pediatric Oncology Group Study. J Clin Oncol 17(12): 3745-3752; 1999.
  • B Ogretmen, JC Barredo, HR Bahadori, AR Safa. Overexpression
  • JD Rowley, S Reshmi, O Sobulu, T Musvee, J Anastasi, S Raimondi, NR Schenider, JC Barredo, ES Cantu, B Schlegerberger, F Behm, NA Doggett, J Borrow, N Zelenik-Le. All Patients With the (11;16)(q23;p13.3) That Involves MLL and CBP Have Treatment-Related Hematologic Disorders. Blood. 90(2): 535-541; 1997.
  • JC Barredo, M Abboud, J Laver. Successful Treatment of Relapsed Infant Acute Lymphoblastic Leukemia with Intensive Antimetabolite-based Chemotherapy. Med Pediatr Oncol. 29(4), 256-259; 1997.
  • AJ Galpin, JD Schuetz, E Masson, Y Yanishevski TW Synold, JC Barredo, C-H Pui, D Campana, MV Relling, WE Evans. Differences in Folylpolyglutamate Synthetase and Dihydrofolate Reductase Expression in B-lineage versus T-lineage Acute Lymphoblastic Leukemia: Mechanisms for Lineage differences in methotrexate Polyglutamylation and Cytotoxicity. Molecular Pharmacology. 52: 155-163; 1997.
  • JC Barredo, U Yusuf, MR Abboud, J Laver. Progressive Chronic Graft vs Host Disease Induced by Cyclosporine A. Bone Marrow Transplantation Bone Marrow Transplantation. 18(3), 659-662;1996.
  • MR Abboud, SM Jackson, JC Barredo, K Holden, J Cure, J Laver. Neurologic complications following bone marrow transplantation for sickle cell disease. Bone Marrow Transplantation. 17(3), 405-407; 1996.
  • JR Priest, J Watterson, L Strong, V Huff, WG Woods, RG Byrd, SH Friend, I Newsham, MD Amylon, A Pappo, DH Mahoney, C Langston, R Heyn, G Kohut, DR Freyer, B Bostrom, MS Richardson, JC Barredo, LP Dehner. Pleuropulmonary Blastoma: A Marker for Familial Disease. J Pediatr 128 (2), 220-224, 1996.
  • JC Barredo, TW Synold, J Laver, C - H Pui, DG Priest, WE Evans. Differences in Constitutive and Post-Methotrexate Folylpolyglutamate Synthetase Activity in B-Lineage and T-Lineage Leukemia. Blood 84 (2), 564-569; 1994.
  • M Abboud, S Jackson, JC Barredo, J Beatty, J Laver. Bone Marrow Transplantation for Sickle Cell Anemia. American Journal of Peds Hem/Onc. 16 (1), 86-89; 1994.
  • JC Barredo, RG Moran. Determinants of Antifolate Cytotoxicity: Folylpolyglutamate Synthetase Activity During Cellular Proliferation and Development. Molecular Pharmacology 42, 687-694; 1992.
  • JH Laver, Fushen Xu, JC Barredo, MR Abboud. Studies on the Effects of Radiation and 4-Hydroperoxycyclophosphamide on the Production of G- and GM-CSF by Stromal Cells. Bone Marrow Transplantation 10, 529-533; 1992.


Best Doctors
Top Doctors
McCallister Research Fellowship, University of Southern California, 1989.
Mitchell I. Rubin Junior Research Award, 1995.
Jolley Foundation Award. Research Award, 1998.
Star Award, Make-a-wish Foundation of South Carolina, 2002.
Mitchell I. Rubin Senior Research Award, 2004.
America’s Best Pediatricians. 2004
International Who’s Who of Professionals. 2005.
America’s Top Doctors for Cancer. 2005
America’s Top Doctors for Cancer. 2006
Castle Connolly Top Doctors 2006
Toppel Family Endowed Chair in Pediatric Hematology-Oncology 2006.


1990 Fellowship
Children's Hospital of Los Angeles
1987 Residency
SUNY DownstateKings County Hosptial Medical Center
1982 M.D.
Universidad Nacional Mayor de San Marcos
1974 Pre-Med
Universidad Nacional Mayor de San Marcos

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